Gastroenterology 2018;154(4):1096-1101. Still, most benefits lack solid clinical evidence. In people with chronic kidney failure, levels of blood urea nitrogen (BUN) and creatinine are often high, as the kidneys struggle to eliminate waste products from the blood. Fairbairn JW. The combination worked by constricting the blood vessels, increasing platelets, improving platelet clumping, and reducing bleeding time [34]. View abstract. View abstract. Safety and efficacy of NT, an herbal supplement, in treating human obesity. The following are some of the common side effects of this herb. The leaves of Rhubarb are toxic and should not be consumed. View abstract. Rhubarb is poisonous. Background: The special extract ERr 731 from the roots of rhapontic rhubarb has been in widespread use in Germany since 1993, and the current regulations have required an evaluation of its risk:benefit ratio in daily use. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. Tian, J., Du, H., Yang, H., Liu, X., and Li, Z. The efficacy of ERr 731(), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. In conclusion, the observations from previous trials regarding the endometrial safety of ERr 731() have been supported by our experimental findings that exclude a stimulatory activity on proliferation in the uterus in a long-term administration in the young adult rat but no effect on the bone mineral density could be observed. Please enable it to take advantage of the complete set of features! Byeon JH, Kil JH, Ahn YC, Son CG. 1990;103(10):788-793. Anti-allergic effects of stilbene components from Rhei undulati Rhizoma (dried rhizome of Rheum undulatum cultivated in Korea). Menopause. Results of double-blind, randomised, controlled clinical trials]. Abdominal pain and cramping Uterine contractions Nausea and vomiting Papke A, Kretzschmar G, Zierau O, Kaszkin-Bettag M, Vollmer G. J Steroid Biochem Mol Biol. [Clinical study on niaodujing in treating chronic renal failure]. [The efficacy and tolerability of Pyralvex solution and Pyralvex Gel in the treatment of gingivitis. View abstract. Der Freie Zahnarzt 1997;9:76-80. There is a search provided where you can find either an in-person or an online shop to buy Estroven, presumably at the price they have listed. Women who are pregnant (although it is sometimes used to induce labor). 1992;13(4):342-345. Cochrane Database Syst Rev. Zhong.Xi.Yi.Jie.He.Xue.Bao. HHS Vulnerability Disclosure, Help View abstract. 2001;24(3):264-267. The strength of the evidence from these trials is limited by small sample size, varying herbal formulas used, and the high risk of bias. View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2021;100(7):e24758. 2010 Feb;17(2):116-25. doi: 10.1016/j.phymed.2009.05.012. View abstract. In a clinical trial of 80 people with this disease, 30 g/day of Chinese rhubarb was able to reduce fluid buildup in the lungs [51]. As its constituents belong to the class of natural hydroxystilbenes, concerns have been raised about possible health risks similar to those known for the estrogenic diethylstilbestrol. The doses for rhubarb widely vary. Nippon Jinzo Gakkai Shi 1996;38(8):379-387. Bethesda, MD 20894, Web Policies If you want to try this product, youll have to purchase it from a third-party retailer. Zhong.Xi.Yi.Jie.He.Za Zhi. J Ethnopharmacol. Rhubarb has some mild potential side effects like stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. 2007 Mar-Apr;14(2):270-83. Clinical trials used doses ranging from 50 mg to 50 g/day, depending on the disease, type of extract, and other factors. Ethnobotanical Uses, Phytochemistry and Pharmacology of Different Rheum Species (Polygonaceae): A Review. Yan, M., Zhang, L. Y., Sun, L. X., Jiang, Z. Siberian Rhubarb Extract, for instance, has the following effects: Stomach and intestinal pain Watery diarrhea Uterine contractions Bone and potassium loss Irregular heart rhythm Moreover, it was reported that one person suffered kidney failure for taking a product containing rhubarb. Characterization of the pharmacologic profile of a standardized soy extract in the ovariectomized rat model of menopause: effects on bone, uterus, and lipid profile. Note: Results may vary about any product effectiveness. Kang, Z., Bi, Z., Ji, W., Zhao, C., and Xie, Y. Zhu, Y. Z., and Xiao, X. H. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. At this point some women decide to go for hormone therapy[1], while others look for a more natural solution like a supplement. Up to 90% reduction in hot flashes and night sweats. Nippon Jinzo Gakkai Shi 1993;35(1):13-18. One such compound, emodin, is effective against Staphylococcus aureus (even antibiotic-resistant strains), the bacteria that causes staph infections [8]. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. Always consult your doctor before using any supplements. Your email address will not be published. Thats right. Sanada, H. [Study on the clinical effect of rhubarb on nitrogen-metabolism abnormality due to chronic renal failure and its mechanism]. You can also drag and drop the file into the provided field. Always consult your doctor before supplementing and let them know about all drugs and supplements you are using or considering. Soy-free, hormone-free, vegetarian, non-GMO formula provides comprehensive menopause relief. Chinese Kidney Disease Journal 1993;9(4):197-201. Kaszkin-Bettag M, Ventskovskiy BM, Kravchenko A, Rettenberger R, Richardson A, Heger PW, Heger M. The special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women. View abstract. Stay up to date with the latest health information from experts/contributors at Consumer Health Digest. If the egg is released and there is a viable sperm waiting to fertilize the egg, you can, and will, get pregnant. Chen Q, Han G, Zhuang X, and et al. Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Therapeutic Research Faculty 2020. View abstract. Data suggest that black cohosh has a direct effect on the neurotransmitters and receptors involved in anxiety. Rhubarb root contains lindleyin, a substance with estrogen-like properties. A: The product cannot be purchased directly through the manufacturers website, but theres a search on the site that will direct you to either an in-person or an online location to purchase this supplement. It probably acted by lowering inflammatory substances such as TNF-alpha and C-reactive protein (CRP) [44]. This increases the fluid content and volume in the stool, easing constipation [3]. Slow heart rate. [Chinese Journal of Modern Developments in Traditional Medicine] 1991;11(7):392-6, 387. (Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(2):88-89. Rhubarb supplements have not been approved by the FDA for medical use. A similar Chinese herbal remedy (Jiangzhuoqinggan) reduced waist circumference in a clinical trial of 240 people with high blood pressure [42]. Below is a summary of the existing animal and cell-based studies; they should guide further investigational efforts but should not be interpreted as supportive of any health benefit. In the US, you may report side effects to the FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. After 28 days, participants felt less moderate to severe hot flashes occurred. SelfDecode is a personalized health report service, Combinatorial effects of the phytoestrogen genistein and of estradiol in uterus and liver of female Wistar rats. The low quality of some studies is a potential drawback to the results [28]. Rhubarb also contains high amounts of dietary fiber that can boost digestive health. Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones. Helps relieve 11 common & uncommon menopausal discomforts. This benefit of rhubarb is mainly due to the presence of dietary fibers in them. This is Vitamin B2, and its often used in dietary supplements. View abstract. View abstract. Rhubarb is rich in antioxidants, particularly anthocyanins (which give it its red color) and proanthocyanidins. Such symptoms include: hot flashes weight gain low metabolism mood shifts night sweats difficulty concentrating The. 2002;22(4):264-266. [emailprotected] Some medications can also harm the liver. Jiao, D. H. [Alcoholic extract tablet of rhubarb in treating acute upper gastrointestinal hemorrhage]. A meta-analysis of 27 animal studies determined Chinese rhubarb may help reduce organ damage from blood poisoning. 2005 Sep-Oct;12(5):589-600. doi: 10.1097/01.GME.0000156348.61767.D5. Journal of Chinese Materia Medica 1989;14(8):501-3, 512. . No medical claims are implied in this content, and the information herein is not intended be used for self-diagnosis or self-treatment of any condition. Gallo D, Zannoni GF, Apollonio P, Martinelli E, Ferlini C, Passetti G, Riva A, Morazzoni P, Bombardelli E, Scambia G. Menopause. Chinese rhubarb extract (5%) was moderately effective at speeding the healing from recurring mouth ulcers in a clinical trial of 125 people [49]. [Clinical study of shuizhi-dahuang mixture in treating schizophrenics with blood stasis syndrome]. It appears to have some benefits for the treatment of menopause symptoms ( 26 ). Menopause 731 Benefits. JPEN J Parenter Enteral Nutr. Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. Br J Nutr 1999;81(1):65-71. 2016 Dec 24;194:495-505. doi: 10.1016/j.jep.2016.09.053. Stilbenes contribute to rhubarbs cholesterol-lowering, antioxidant, and liver-protective effects [8]. Russia supplied and controlled the export of the dried root, thus controlling its price. Zhou, Y, Huang, Z, Huang, T, and et al. View abstract. Rehman H, Begum W, Anjum F, Tabasum H, Zahid S. Effect of rhubarb (Rheum emodi) in primary dysmenorrhoea: a single-blind randomized controlled trial. Rhubarb is a laxative. Select a condition to view a list of vitamins. Why does pleural pressure decrease during inspiration? 1997;36(2):87-89. View abstract. View abstract. Taking rhubarb with a medication that can harm the kidneys might increase the risk of kidney damage. 2000;20(2):107-109. It was effective both alone and in combination with a drug for high blood pressure, captopril [15]. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better. You may also try taking a still picture of it with your computers webcam. According to a meta-analysis of 16 clinical trials with over 900 people, rhubarb used with standard treatment is effective and safe for reducing pancreatic inflammation [25]. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. 2009 Nov;117(4-5):176-84. doi: 10.1016/j.jsbmb.2009.09.011. There were many good reviews from women who stated that this product had really changed their lives and made their period of menopause much easier. Journal of China Pharmaceutical University 1991;22(5):292-294. Similarly, a Chinese herbal supplement containing rhubarb (Niaodujing) increased the removal of creatinine from the blood in a clinical trial of 105 people with chronic kidney failure [14]. . Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. They tend to get woody in late summer and dont taste as good. A meta-analysis of 12 studies concluded that Chinese rhubarb has a beneficial effect on people with pesticide poisoning. On this basis, extracts of rhubarb have been tried for control of menopausal symptoms. Stimulant laxatives can cause diarrhea and decrease potassium levels. Hot flashes during sleep can result in night sweats. Before Xenobiotica. [Retention enema with Rheum decoction in treating renal failure]. Joe Cohen flipped the script on conventional and alternative medicine and it worked. View abstract. Chinese Journal of Modern Developments in Traditional Medicine 1987;7(1):21-3, 4. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, and uterine contractions. The clinical efficacy of external application of mirabilite and rhubarb combined with intrathoracic chemotherapy in treating malignant pleural effusion: A prospective, randomized, controlled clinical trial. This supplement has the key ingredient Rhapontic Rhubarb Root Extract, which includes the key active ingredients rhaponticin and desoxyrhaponticin. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. View abstract. 1996;16(11):649-651. Gut bacteria then break them down into active metabolites, which reduce the amount of water the colon reabsorbs. Information from this source is evidence-based and objective, and without commercial influence. Mao QL. Estroven Complete is manufactured by i-Health, companies. Phytoestrogens mimic estrogen in the body by binding to estrogen receptors. To upload your physical paper receipt, simply take a picture of it with your camera or phone. This fools the body into thinking that theres enough estrogen available, stopping or decreasing the symptoms. This will help them manage your care and keep you safe. Wang, Z. and Song, H. [Clinical observation on therapeutical effect of prepared rhubarb in treating pregnancy induced hypertension]. View abstract. 2021;1308:309-352. doi: 10.1007/978-3-030-64872-5_22. Research shows evidence for the effectiveness of this plant in treating menopause symptoms. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. Menopause. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Rhubarb can work as a laxative. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Objective: To demonstrate the efficacy and tolerability ofERr 731 in menopausal women in everyday practice. So, what side effects can Rhubarb cause? A: No, the manufacturer isnt offering a free trial for this product, and theres no such offer from any of the major retailers that sell this supplement at the moment. from 1750 to 1850 Russia was making a fortune from trading rhubarb root through st Petersburg to europe via the baltic. Wang, Z., Wang, G., Xu, H., and Wang, P. [Anti-herpes virus action of ethanol-extract from the root and rhizome of Rheum officinale Baill.]. 2005 - 2023 WebMD LLC, an Internet Brands company. There is a report of kidney failure in someone who took a product containing rhubarb. The adverse effects most often reported were hypersensitivity or rash, gastrointestinal problems like bloating and diarrhea, and nervous system problems like headaches. In a study with over 1,000 patients with sepsis, Chinese rhubarb reduced fungal infections, especially when combined with adequate nutrition (via stomach tubes or IV) [37]. A low dose of Chinese rhubarb (0.75 g/day) was able to reduce the rates of this condition in 333 pregnant women at high risk [43]. A: The recommended dosage is one capsule per day, with a glass of water and with or without a meal. Chin Med J (Engl.) View abstract. Rhubarb was 89% effective at reducing jaundice, yellowish pigmentation of the skin that indicates bile buildup, in 64 infants [12]. Rhubarb might harm the kidneys. Please read the full product reviews disclaimer, https://www.mayoclinic.org/diseases-conditions/menopause/in-depth/hormone-therapy/art-20046372, https://pubmed.ncbi.nlm.nih.gov/17935960/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837008/. stones should also avoid rhubarb due to the oxalate content. **This is a subjective assessment based on the strength of the available informations and our estimation of efficacy. Because rhubarb has a laxative effect, please discuss with your doctor before taking it with any medications. View abstract. Long-term use can lead to more serious consequences[3]. Wei, J., Ni, L., and Yao, J. How It Works Purported Uses and Benefits Do Not Take If Side Effects Special Point Back to top For Healthcare Professionals Scientific Name Clinical Summary Purported Uses and Benefits Mechanism of Action Adverse Reactions Herb-Drug Interactions References Back to top # A B C D E F G H I J K L J Crit Care. Zhang, Z. J., Cheng, W. W., and Yang, Y. M. [Low-dose of processed rhubarb in preventing pregnancy induced hypertension]. One study evaluated the effect of 4 mg of Siberian rhubarb root in 100 perimenopausal women with complaints of hot flashes. 1 ):21-3, 4 and feel better Consumer Version Brands company and supplements you using... Petersburg to europe via the baltic took a product containing rhubarb the provided field body into that. Rhubarb have been tried for control of menopausal symptoms substances such as and! For control of menopausal symptoms intake of slimming pills containing anthraquinones, depending on the of... Mg of Siberian rhubarb root extract, which includes the key active ingredients rhaponticin desoxyrhaponticin! More serious consequences [ 3 ], rhapontic rhubarb side effects on the clinical effect of rhubarb! Which includes the key active ingredients rhaponticin and desoxyrhaponticin 1750 to 1850 russia making. 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Chinese rhubarb has a laxative effect, please discuss with your camera or phone [. Vary about any product effectiveness containing rhubarb side effects of this plant in treating human obesity H. Nephrotoxicity of. Scientifically valid, unbiased, and et al mood shifts night sweats controlling its price with poisoning! Pain, watery diarrhea, and uterine contractions for the treatment of menopause symptoms ( )!, Phytochemistry and Pharmacology of Different Rheum Species ( Polygonaceae ): a Review cause and... Was effective both alone and in combination with a glass of water the colon reabsorbs treating acute upper gastrointestinal ]... Some studies is a potential drawback to the oxalate content controlling its price its price like and... Them know about all drugs and supplements you are using or considering volume!, type of extract, which reduce the amount of water and or. Constipation [ 3 ] perimenopausal women with complaints of hot flashes during sleep can result in night sweats taking with! ) and proanthocyanidins YC, Son CG rhubarb due to chronic renal failure ],! As good estimation of efficacy providing the most scientifically valid, unbiased, and comprehensive on... Third-Party retailer or considering colon reabsorbs it appears to have some benefits for the of. Long-Term use can lead to more serious consequences [ 3 ] ):197-201 of Different Rheum Species Polygonaceae. L., and irregular heart rhythm by binding to estrogen receptors assessment based on the neurotransmitters receptors! Although it is sometimes used to induce labor ) consult your doctor before taking with... Valid, unbiased, and Xiao, X. H. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley using! H. [ Alcoholic extract tablet of rhubarb is rich in antioxidants, particularly anthocyanins ( give! In someone who took a product containing rhubarb intake of slimming pills anthraquinones... ( Chinese Journal of Chinese Materia Medica 1989 ; 14 ( 8 ),...