I gave my almost 10 year old chihuahua mix (11lbs) his first dose on Wednesday and he has started coughing and sputtering since Thursday nite. How is your cockapoo doing now? I will NEVER give this drug to my dogs! He did blood work and found that the phosphorus levels in her blood were way to low and that was causing the neurogical problems and it was most likely from Simparica Trio. She is shaking and panting heavy. Any other alternatives that are not harmful? I read all the above and it makes me sad. She continued to have seizures even she was on phenobarbital. So sorry! However a spinal tap of the fluid surrounding the spinal cord would be need to prove your dog indeed has spinal meningitis and then to treat for the specific bacterium or viral causes. Skin issues. Lethargic and confused. I took him to the emergency hosp. The vet said not to give it. Advised I could call Simparica for reimbursement or to report side effects. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. One common alternative is to give Heartgard for heartworms and intestinal parasites along with Bravecto to prevent fleas and ticks, but there are other choices out there. Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. Hes very lethargic and constant vomiting! We gave Simparica two days ago and he's not had an appetite, he's eating grass, is drinking a lot of water and sleeping. Which Type of Dog Fence Is Right For Your Pet? Ticks are horrible here in Maine. Im convinced the medicine caused this and now she cant walk. However, since on the market there have been thousands of reports of seizure in otherwise healthy dogs. Pyrantel Pamoate got its approval for the first time by the FDA for the purpose in 1977. But he still is suffering from lethargy, polyuria and polydispia basically still drinks and pees non stop. I am so sorry to all of you and my heart goes out to you and your babies. Dogs Naturally Market is a good source to check out. Im convinced it was caused by this drug. The diarrhea also went away yesterday evening. Thank you all so much!!!! My Miles is having this SAME issues, started Simparico Trio in May and he got his second does June 1, by June 5th he wont eat, walk and or bark! But I have heard of other dogs who recover, or who continue having seizures but not fatal. Vet prescribed this for my 12 week old border collie Lab mix. Simparica Trio contains three active ingredients . In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. I just want to cry! It is better but not gone. Vets have told us repeatedly that it can't be the medication. They gave him IV glucose to raise his Potassium level. We did abx, shampoos changed food. But anyways - the other night , his feet collapsed from under him & he fainted . Reported this to FDA today-, My 14 year old was up on simparica about a year ago and her whole demeanor has changed. Later in the fall I noticed some leg tremors when she squatted. He has no appetite, wont drink water and his mouth is so dry. Although the price may be even lower via online pharmacies, Zoetis only guarantees the product when purchased directly though your vet (in the clinic or via their online pharmacy). Was prescribed Simparica Trio for my Catahula dog with no medical issues. I gave the 1st one to my dog, 1st of this month. This is so awful. No this puppy hasnt had seizures and I came to this forum to see other problems with this medicine. What You Need to Know About the Lyme Vaccine for Dogs. However, the following side effects are seen in less than 1 dog in 10,000 . She was due to get the next dosage this week and i am choosing not to give it to her with the hopes that it will be out of her system and her Liver levels will go down. Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . I would, still boil chicken, carrots, potatoes for his meals. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. My chihuahua is 18 days since the last seizure episode, she is finally playing again but I'm noticing her shaking her head on the left side and it's very odd. Was hospitalized for 2 1/2 days. No appetite, not like Charlie. A couple of weeks later she had lost weight from not eating. Puppy is having seizures and has aspirated pneumonia. I will never give this again! Hoping that these side effects dont get worse and subside soon . She's been given this dosage for over a year. Update on my Labradoodle who started seizures just a few hours after receiving first dose of Simparica on T-Day 2020 it is March 2021 and my Vet put my dog on Phenobarbital for anti-seizure med. Just gave 3yr old OES first dose yesterday (her half sister got one too) and today she has uncontrolled urination. Advised her to put a big note on our account that she is never to have this again. Took her to her Vet where I was told she had another tremor. I sure hope he makes it! I also am seeking information as to if there is a class action suit against this company because there should be. Not even going to risk it . Your veterinarian may recommend a heartworm test if you are using Simparica Trio. It causes paralysis that leads to death of hookworms and roundworms. Never ever again with this med for him. How is your dog doing? His neck felt swollen and he was panting heavily gasping for air. But this month we are at day 7 and I expect the diarrhea it to continue. Good appetite and no digestive issues (never had that symptom). It's been the worst 2 months. I just hope he makes it to his life expectancy . After seeing his condition worsen, that night we took him to an after hours urgent care. Duke is 7 month boxer And we have the simpatica on Monday and cant believe this stools Hopefully it doesnt last long. On May 15th 2022 when she was due her flea and tick topical I gave her the free dose instead.Before 24 hrs she started with diarrhea yellow and orange then vomiting started. Getting him to go out was nearly impossible. Pyrantel only treats parasites found in the gastrointestinal tract because it does not absorb well into the bloodstream. They have increased and worsened over the last 3 months. Gave our Brit simparica in October and shortly thereafter he had a seizure. These side effects are usually mild and resolve on their own within a few days. So now after $90.00 spent on three pills this month, I decide to look up the answers myself. The next morning, she had uncontrollable tremors and could not walk without falling down. Thousands more wasted with antibodies test for the Lepto guess (different ER vet) to also come back false positive due to vaccines.. my poor baby already had a rough life being abandoned. AVOID THIS PILL! I wish I would have seen this site before I gave it my Matty. and lack of appetite. Started our 8 month old rescued golden retriever on simpatico trio in February as had our rescued border collie mix on it for last year. So sorry to hear, and good for you in recognizing the problem! They were good to deal with. May not be from this med but too strange to at least not think about it. Seizures continue and its Monday. Be aware! Them I took him to a vet for check up and to my horror, he has fleas and a tick. For those who lost their dear companions from this medicine my heart goes out to you all. By Sunday he is having liquid diarrhea! This is still going on weeks later. However, doing nothing is better than giving her the Simparica. Hoping you are the lucky ones!! With Entyce she is getting her appetite back and seems a little better. I just wish I could find a vet who honestly loves my animals as much as I do. I got my dog Josey up to let him out to pee. I gave my dog simparica trio. All went well until this morning. She is only 6 and was so full of life and energy. My 3 month old shih tux Juno took her second dose last week and for the last two days shes vomited and has been eating grass nonstop! This Tuesday the 17th I had given my dog simparica trio for 27lbs dose. we gave our dane Simperica Brown about a day or so ago and all the sudden my sweet girl is having seizures. Both products are safe for dogs when administered according to the label directions. I thought maybe he got into something. I just hope and pray she gets better. After about 35 days he was back to normal. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. (toy aussie & corgi). Thanks all for sharing your experiences. I am starting to get scared they are both 80 lbs and the other dog is. She text me asking if she ever had seizures before. Today, he wouldn't eat or drink any water. She's pacing and wants to eat grass. I called the vet and of course they do not think it's the pill but I know it was. There was no clear diagnosis but it was clearly neurological. For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. I hope this product is no longer sold anywhere. I have her home, but she has been at the Emergency Vet last night, and her normal vet all day. I want to cry I wish I could get it out of her system after reading these comments. I will never use this product again!!!!! This leads to tick and flea death. Another call to vet asking for an appt - seems like an an emergency now? , My healthy six years old heidi also passed away after given simparica by her childhood vet causing seizures which got so bad u cudnt keep a count follower hy liver failure.dont give ny tick fleas medication orally. Vet said "cant be Simparica because he had 9 days ago". They were taking Simperica for flea/tick and Heartguard to prevent heart worms. Most common is vomitting. Simparica Oral Flea & Tick Preventive For Dogs 2.8-5.5 Lbs (Yellow) 6 Pack; Simparica Oral Flea & Tick Preventive For Dogs 5.6-11 Lbs (Purple) 3 Pack He never ever used to do this. Eyes roll back. It is Now 3 pm and Lily is on her way to the animal hospital and most likely going to have to spend the night, we will flush her with iv and hope It helps Flush It out Of her system. He has bad allergies and oral works best. I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. Random vomitting is no fun either. So if your dog actually has meningitis then that wouldn't be related to having given him Simparico but a separate matter altogether. Couple of days ago, I took my other doxie (Maddie) into my vet, for shots, he did the heart worm test and recommended Simparica. Does this sound familiar to anyone? After 9 days he began vomitting, even water, and mouth chattering like he was scared. 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