2013;98(1):207-217. 2018; doi: 10.1016/j.clnu.2018.05.017. 2013;142(4):327-345. Vinceti M, Filippini T, Crippa A, de Sesmaisons A, Wise LA, Orsini N. Meta-analysis of potassium intake and the risk of stroke. https://pubchem.ncbi.nlm.nih.gov/compound/13344, https://www.cfsanappsexternal.fda.gov/scripts/fdcc/index.cfm?set=FoodSubstances&id=POTASSIUMGLUCONATE, https://www.cfsanappsexternal.fda.gov/scripts/fdcc/index.cfm?set=FoodSubstances&id=POTASSIUMCITRATE, https://www.fda.gov/food/food-additives-petitions/food-additive-status-list, https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019071s012lbl.pdf, Potassium Citrate Information for Consumers, Potassium Citrate Information for Healthcare Professionals, Renal tubular acidosis (when the kidneys do not properly remove acids from the blood), Kidney stones (crystal-like formations in the kidneys). 11 Researchers found that compared to those with higher potassium levels (4.5mmol/L), those with lower levels (<4.0mmol/L) had significantly higher fasting glucose. The purpose is to alleviate nighttime leg cramps. There are a variety of other potassium salt medications available as well, such as potassium citrate and potassium gluconate, that are prescribed for different reasons, most notably to balance out our body acid-base levels. I take Lipitor every day for cholesterol. It is also used to prevent kidney stones that may occur with National Institutes of Health, Lambert H, Frassetto L, Moore JB, et al. You may opt-out of email communications at any time by clicking on Am J Med. Potassium citrate may also be used for other purposes other than those listed in this medication guide. Centers for Disease Control and Prevention. 2015;593(6):1361-1382. Jane Higdon, Ph.D. Meta-analyses have also reported a dose-response relationship between the intake of potassium and the lowering of blood pressure (42, 43). Int J Cardiol. (PubMed), 35. An analysis of the 2014 US National Health and Nutrition Examination Survey (NHANES) showed an increase in systolic blood pressure with increasing sodium excretion and increasing sodium-to-potassium ratio in the urine (37). 2018;10(9). In rare cases, habitual consumption of large amounts of black licorice has resulted in hypokalemia (7, 8). Both supplements effectively treat hypokalemia (low blood levels of potassium). ASH position paper: dietary approaches to lower blood pressure. Urolithiasis. Cochrane Database Syst Rev. Call your doctor at once if you have: severe vomiting or stomach pain; high blood potassium-- nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or. Therefore, here is a complete list of foods rich in potassium: flax seeds, pistachios, beet greens, raisins, almonds, oat bran, dates, white beans, lima beans, spinach, soybeans, chia seeds, avocado, sweet potatoes, potatoes, kiwi, prunes,lentils, bananas, broccoli, onion, chickpeas, cantaloupe, winter squash, celery, apricots,orange, mango,radish, tomatoes, millet, strawberries, pineapples, pear, and apples. Potassium's cardiovascular protective mechanisms. (PubMed), 36. (PubMed), 38. Doctors typically provide answers within 24 hours. (PubMed), 46. Mumoli N, Cei M. Licorice-induced hypokalemia. Potassium and health. 2. 1985 Sep;79(3):284-8. doi: 10.1016/0002-9343(85)90305-5. If you take 20 MEQ of POT chloride and run out it states that 8.5 tablets of POT glu is equal to 10 MEQ of POT Chloride. However, most people will not take more than 100 mEq a day. Accessed 11/30/18. Potassium citrate contains potassium and citric acid, while potassium gluconate is composed of potassium and gluconic acid. Mente A, O'Donnell M, Rangarajan S, et al. Consult your physician if you are taking potassium citrate or potassium chloride. 2016;8: E444. JAMA. 2015;33(8):1509-1520. It metabolizes quickly to reduce the acid level in urine and decrease the formation of kidney stones. I was tasked with comparing Advair, Breo and Trelegy. Ann Intern Med 1997;126:497-504. It is used to treat a kidney stone condition called renal tubular acidosis. Various mechanisms explain how certain medications can lead to potassium depletion. While the treatment based on potassium, sodium, chloride, and magnesium supplementation in addition to other The key difference between Potassium citrate and potassium gluconate is, Potassium citrate is produced by mixing potassium carbonate or bicarbonate with a solution of citric acid whereas potassium gluconate is produced by the reaction between gluconic acid and potassium. San Diego: Academic Press; 2001:357-378. Ionic reactions. Its used to replenish low blood potassium, to maintain normal levels, or to avoid potassium depletion during specific drug therapies and certain diseases. Make sure your doctor knows about any other medications you are taking. This site needs JavaScript to work properly. Experimental evaluation of relative intestinal toxicity. And potassium citrate is used for certain types of kidney stones. ChildrenDose must be determined by your doctor. It is important to discuss your options with your doctor as there are a variety of factors that need to be taken into consideration in regards to regaining normal potassium levels. Potassium chloride or potassium citrate? Finally, in a recent meta-analysis of 16 observational studies, each 1-unit increase in the dietary sodium-to-potassium ratio was found to be associated with a 22% higher risk of stroke (12). Academy of Nutrition and Dietetics. Severe hypokalemia may result in muscular paralysis or abnormal heart rhythms (cardiac arrhythmias) that can be fatal (1, 6). Potassium chloride is also Intestinal ulceration has been reported after the use of enteric-coated potassium chloride tablets. Your doctor may change the dose if needed. Both potassium citrate and Bethesda, MD 20894, Web Policies Among other differences, the daily intake of sodium chloride (salt) in modern diets is about three times higher than the daily intake of potassium on a molar basis, whereas salt intake in primitive cultures is about seven times lower than potassium intake (13). Association between urinary sodium and potassium excretion and blood pressure among adults in the United States: National Health and Nutrition Examination Survey, 2014. BMJ. Amazon stocks potassium salt in its own brand as well as other brands. Both dosage regimens led to reductions in serum PINP concentration and urine NTX concentration, yet evidence of an effect was stronger with the lowest dose (median dose administered, 3,160 mg/day) rather than with the highest dose (median dose administered, 4,760 mg/day). 2013;4(3):368s-377s. Adults and teenagers16 to 24 mEq a day, divided into two or three smaller doses during the day. Warnings Potassium chloride is a form of potassium for people who PMC Which is better for summer heat? Int J Cardiol. Penicillins formulated as sodium salts also stimulate potassium excretion. Low dietary potassium intake alone does not generally result in hypokalemia. Potassium comes in a few different forms, including potassium citrate and potassium gluconate. Can You Take A Z-Pak If You Have A Penicillin Allergy? By lowering the uric acid level, potassium citrate is helpful in preventing or treating gout and certain metabolic disorders resulting from kidney disease 3. 2010;4(2):79-89. Sodium, chloride and potassium. In general, the daily (PubMed), 43. Potassium is important for good body health and is necessary for the heart, kidneys and other organs to work well together. Thiazide treatment alone reduced serum potassium, urinary calcium and citrate without affecting urinary pH. Citrate uses a differnt salt. Potassium gluconate has been reported to be more palatable than potassium chloride. Therefore, if your potassium gluconate supplement contains 550 mg, it only contains around 91 mg of elemental potassium. Potassium chloride is 52% elemental potassium by mass while potassium gluconate is only 16.7% elemental potassium by mass. Endocrinol Metab Clin North Am. Your doctor may change the dose if needed. Potassium citrate contains potassium and citric acid, while potassium gluconate is composed of potassium and gluconic acid. What is the difference between potassium gluconate and potassium citrate? Nutr Metab Cardiovasc Dis. Potassium chloride is also better absorbed and is generally the potassium of choice to replace a potassium deficiency. Potassium is the 3rd most abundant mineral in the human body and is vital for the maintenance of acid-base balance as well as for the maintenance of normal whole-body and cellular fluid levels. If you are on a salt (sodium)-restricted diet, check with your doctor before using tomato juice to dilute your medicine. Urinary alkalinization with supplemental potassium citrate is used in stone formers to reduce the risk of recurrent stone formation (reviewed in 22). What Is the Difference Between Magnesium Glycinate and Magnesium Gluconate? Difference of meds: Potassium gluconate is the potassium salt of the conjugate base of gluconic acid. Potassium gluconate and potassium citrate are potassium supplements available over the counter and by prescription 3. 47. Hi docs, do you think it's bad to take potassium chloride with potassium citrate? 1997;81(3):611-639. They include fatigue, muscle weakness and cramps, and intestinal paralysis, which may lead to bloating, constipation, and abdominal pain. Am J Clin Nutr. Lancet. (PubMed), 29. Feel free to send him an email at Hello@HelloPharmacist.com! Please feel free to reach out to him directly if you have any inquiries or want to connect! The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis. The Linus Pauling Institute recommends the consumption of a diet high in potassium-rich foods (see Sources), especially fruit, vegetables, nuts, and dairy products to ensure adequate potassium intakes. Moreover, avoid these supplements if you: Interaction with alcohol is unknown, thus, stay on the safe side and avoid alcoholic beverages while using these supplements. By using our website, you consent to our use of cookies. Since your potassium gluconate supplement contains 550mg per pill, that equates to about 8.5 tablets. Kong SH, Kim JH, Hong AR, Lee JH, Kim SW, Shin CS. Nutr Today. Her work has been published in "Prevention," "Nurseweek" and "Senior Life." [Your name] is not affiliated or endorsed by the Linus Pauling Institute or Oregon State University. J Am Soc Hypertens. WebThe effectiveness of potassium citrate as a potassium supplement was compared to that of potassium chloride in 13 patients with calcium nephrolithiasis treated with thiazide. It is used to treat a kidney stone condition called renal tubular acidosis. Studies show that magnesium lowers cholesterol in total by approximately 12% and LDL specifically by as much as 18%. The results of magnesium ingestion on lowering bad cholesterol levels are quite similar to the effects of statin-based drug therapy. (PubMed), 16. Most studies used supplemental potassium doses between 2,340 and 2,535 mg/day (60-65 mmol/L). Below, I get into the specifics regarding how to discern how much elementalpotassium is in each product. (PubMed), 44. 2017;2(19):e94920. Table 3 lists the classes of medications known to increase the risk of hyperkalemia (elevated serum potassium) in patients who also use potassium supplements (50, 51, 54). There is a problem with Both may be used to supplement potassium in a person's diet. WebPotassium citrate is an alkalizing agent. Washington, D.C.: National Academy Press; 2019:121-154. Oregon State University Linus Pauling Institute: Potassium, University of Maryland Medical Center: Potassium, Potassium. government site. The usual dose is 2 to 3 mEq per kilogram (kg) (0.9 to 1.36 mEq per pound) of body weight a day, taken in smaller doses during the day. Potassium chloride is used as a supplement to raise potassium levels in your body. Dietary potassium intake of 4.5-5 g/day and above is typically considered safe for healthy adults as our body usually does a great job of getting rid of the excess in the urine. (PubMed), 11. Liability for individual actions or omissions based upon the contents of this site is expressly disclaimed. Natural Medicines. The amount of medicine that you take depends on the strength of the medicine. A dietary survey in the US indicated that the average dietary potassium intake was 2,408 mg/day for adult women and 3,172 mg/day for adult men (47). For these, please consult a doctor (virtually or in person). Linus Pauling Institute It is responsible for transmission of electrical impulses in the heart which control heart beat. Clin Nutr. Hendler SS, Rorvik DR. PDR for Nutrititional Supplements. Although these observational studies suggest a link between potassium intakes and bone health, they cannot establish whether there is a cause-and-effect relationship. We answer our latest question regarding the difference between dietary potassium from foods and potassium medication to treat hypokalemia (low potassium). One of the preferred forms of potassium for a ketogenic diet would be Potassium CHLORIDE. Its formula is: c6h11ko7. What is the evidence base for a potassium requirement? 1985 Jul;134(1):11-9. doi: 10.1016/s0022-5347(17)46962-x. A low potassium intake may be one factor which leads to the Formerly used in: Qualitative cation tests. Trans Assoc Am Physicians. Potassium citrate and potassium chloride are forms of the mineral potassium prepared in two different ways. The Dietary Reference Intakes (DRIs) for potassium have been recently revised by the Food and Nutrition Board (FNB) of the National Academy of Medicine. Potassium concentrations are about 30 times higher inside than outside cells, while sodium concentrations are more than 10 times lower inside than outside cells. Been taking potassium chloride for 4 yrs. To learn more, please visit our. 2018;319(12):1209-1220. 49. Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials. Since muscle activity controls numerous bodily activities, this mineral is important for a variety of normal body functions, including digestion. A diet rich in fruit and vegetables that supplies 2.6-3.4g/day of potassium (see AI) should contribute to maintaining a low risk of chronic disease in generally healthy older adults. This little sodium-potassium pump partially controls that energy powering your metabolism. Differing effects of supplemental KCl and KHCO3: pathophysiological and clinical implications. HealthTap uses cookies to enhance your site experience and for analytics and advertising purposes. Potassium citrate and potassium gluconate versus potassium chloride. And decrease the formation of kidney stones supplementation with alkaline potassium salts on bone metabolism: a.. At any time by clicking on Am J Med this little sodium-potassium pump partially controls that energy powering metabolism. Rhythms ( cardiac arrhythmias ) that can be fatal ( 1, 6 ) Glycinate and Magnesium gluconate three doses... In hypokalemia ( 7, 8 ) dietary potassium from foods and potassium gluconate supplement 550... 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