Himeji, M., Ohtsuki, T., Fukazawa, H., Tanaka, M., Yazaki, S., Ui, S., Nishio, K., Yamamoto, H., Tasaka, K., and Mimura, A. 2-1-2010;84(2):137-144. Studies in humans are quite limited. 5-17-2011;135(2):359-368. View abstract. From diagnosis to treatment, our experts provide the care and support you need, when you need it. J Ethnopharmacol. View abstract. J Med Chem 10-21-2004;47(22):5555-5566. Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. Am J Chin Med 2008;36(3):517-540. Whether co-administration of garlic has negative influence on Scutellaria baicalensis Georgi in treating models rats with pelvic inflammation? Zhou J, Qu F, Yu Y, et al. By inhibiting tyrosinase, Scutellaria baicalensis root extract may be able to reduce abnormal pigmentation associated with aging and exposure to UV light. Please do not use SMS English, Short Text and Words like hi, hello. A number of constituents including flavonoids are thought to be responsible for these activities. View abstract. Acta Pharmacol Sin. Accessed Sept 30, 2016. Clin Pharmacol Ther 2007;82:726-33. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. Intern Med J. Cancer Lett. Lixuan, Z., Jingcheng, D., Wenqin, Y., Jianhua, H., Baojun, L., and Xiaotao, F. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models. J Ethnopharmacol. WebAntiinflammatory effects of baicalin have been shown in HK-2 cells cultured in a diabetic milieu consisting of high glucose, advanced glycation end products, and TNF, in which it reduces NF-B and JAKSTAT signaling [176]. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. All rights reserved. View abstract. View abstract. Taking Baikal skullcap might decrease how well the body gets rid of lithium. Tell your healthcare providers about any dietary supplements youre taking, such as herbs, vitamins, minerals, and natural or home remedies. Phytother Res 2000;14:210-2. 2nd ed. 4-26-2011;135(1):179-185. Diabetes: Baikal skullcap can affect blood sugar levels in people with diabetes. Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. This will help them manage your care and keep you safe. Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. Yin, F., Liu, J., Ji, X., Wang, Y., Zidichouski, J., and Zhang, J. Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Abeta aggregation in SH-SY5Y cells. Curr Drug Targets.Cardiovasc.Haematol.Disord 2005;5(2):177-184. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. Chen, H. H., Hong, H. J., Chou, Y. H., Cheng, T. H., Chen, J. J., and Lin, H. Inhibition of cyclic strain-induced endothelin-1 secretion by baicalein in human umbilical vein endothelial cells. Information from this source is evidence-based and objective, and without commercial influence. View abstract. Liu, J. J., Huang, T. S., Cheng, W. F., and Lu, F. J. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. A preliminary study of S. baicalensis along with metformin appeared to improved glucose tolerance, inflammation, and gut microbiota in patients with type 2 diabetes(23). Afr J Tradit.Complement Altern Med 2010;7(4):339-349. Contact Dermatitis. View abstract. Eur J Drug Metab Pharmacokinet. The root has been used in Chinese medicine for psychiatric disorders. View abstract. Check your mobile for SMS (Didn't get the message, repeat Step 1). Shang, Y. Zhang S, Cheng Z, Huang B, and Li J. 2008;6(1):103-8. Armstrong, T. S. and Gilbert, M. R. Use of complementary and alternative medical therapy by patients with primary brain tumors. 2019;49(4):544-546. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. Vopr.Onkol. 2008;31(5):707-710. Xu, X. F., Cai, B. L., Guan, S. M., Li, Y., Wu, J. View abstract. Baikal skullcap might also cause sleepiness and drowsiness. WebSummary: As a traditional Chinese herbal medicine, Scutellaria baicalensis has shown significant effects on the treatment of various diseases, especially hepatitis, diarrhoea, vomiting and high blood pressure. View abstract. Taking Baikal skullcap with these medications might decrease how well the medication works. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. 11-15-2009;171(1-3):508-513. Li T.T, Xu H.M, and Liang Z.W. The root has been used Mol Pharmacol 2001;60(3):507-513. Cancer Treat Rev 2009;35(1):57-68. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. Clin Pharmacol Ther 2007;82:726-33. View abstract. Cheng, K. T., Huang, Y. C., Lin, Y. S., Su, B., and Chen, C. M. Effects of baicalin on the gene expression of surfactant protein A (SP-A) in lung adenocarcinoma cell line H441. Zhang CZ, Wang SX, Zhang Y, et al. J Biomed.Sci 2009;16:27. Moreover, many safety tests are not done; therefore, the medicines effectiveness and benefits are not completely known. Arch Dis Child 1993;68:468-71. Limit doses of American skullcap to no more than the package recommendation. J Med Food 2014;17(6):707-13. Have a cup of it daily. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. Homma, M., Oka, K., Taniguchi, C., Niitsuma, T., and Hayashi, T. Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. Nontoxic; LD 50 is tested, none. Broncel, M. [Antiatherosclerotic properties of flavones from the roots of Scutellaria baicalensis Georgi]. Some medications are changed and broken down by the liver. Side Effects Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. Therapeutic effect of Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism rats. 2020;318(1):E52-E61. View abstract. View abstract. A Medicinal Plant Extract of Scutellaria Baicalensis and Acacia Catechu Reduced LPS-Stimulated Gene Expression in Immune Cells: A Comprehensive Genomic Study Using QPCR, ELISA, and Microarray. September 2012. Wang R.T, Zhang J.X, and Dong Y.J. Chen et C. Ling and Scutellaria baicalensis Georgi. Kowalczyk, E., Krzesinski, P., Kura, M., Niedworok, J., Kowalski, J., and Blaszczyk, J. International Journal of Pharmacology 2010;6(2):81-88. View abstract. Razina, T. G., Zueva, E. P., Litvinenko, V. I., and Kovalev, I. P. [A semisynthetic flavonoid from the Baikal skullcap (Scutellaria baicalensis) as an agent to enhance the efficacy of chemotherapy in experimental tumors]. Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer. Int J Cancer 5-1-2007;120(9):2019-2027. Kong XT, Fang HT, Jiang GQ, et al. This side effect does not appear to be common and might only occur in people who have a type of allergic reaction to it. In animal models, attenuation of asthma was attributed to reduced airway injury and restored mitochondrial function(19). These medications include atorvastatin (Lipitor), cerivastatin (Baycol), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), and simvastatin (Zocor). The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Mol Nutr Food Res 2008;52(11):1349-1357. View abstract. Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. View abstract. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others. Wang, Z. Planta Med 2000;66(8):694-698. Wu, J., Hu, D., and Wang, K. X. Phytochemistry 2011;72(8):752-760. Make an infusion of Scutellaria Macrantha root. [Effects of Honeysuckle flower and Scutellaria Baicalensis Georgi on constraction and electric activity of rabbit small intestine smooth muscle]. Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others. Most studies have been done in the lab rather than in humans, and suggest anti-inflammatory and antioxidant activity. View abstract. Bull Exp Biol Med 2002;134(1):47-49. Yoo, H. H., Park, J. H., and Kwon, S. W. In vitro cytotoxic activity of some Korean medicinal plants on human cancer cell lines: enhancement in cytotoxicity by heat processing. Kim M, Lee BC. View abstract. View abstract. Skin contact Rinse skin with water/shower. This herb is often used alone, whereas many times, it is used with other herbs in combination. J Agric Food Chem 4-23-2008;56(8):2838-2845. Kaplya, O. View abstract. Contact Dermatitis. Ren S, Cao D., Yang J, and et al. Cancer Lett. Chen, L. G., Hung, L. Y., Tsai, K. W., Pan, Y. S., Tsai, Y. D., Li, Y. Cancer Lett. But there is not enough information to know if Baikal skullcap is the cause of these side effects. Mol Biol (Mosk) 2009;43(6):1082-1087. View abstract. View abstract. Guangxi Zhiwu 2008;28(3):373-378. [Analysis of main flavonoids contents of Scutellaria baicalensis]. Planta Med 2010;76(7):678-682. 4-12-2011;134(3):884-891. Anesth Analg 2003;97:1724-9. View abstract. View abstract. Taking Baikal skullcap along with sedative medications might cause too much sleepiness. Zhang CZ, Wang SX, Zhang Y, et al. Li, H. N., Nie, F. F., Liu, W., Dai, Q. S., Lu, N., Qi, Q., Li, Z. Y., You, Q. D., and Guo, Q. L. Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. Chinese journal of modern developments in traditional medicine 1990;10(5):278-9. B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. View abstract. View abstract. Blach-Olszewska, Z., Jatczak, B., Rak, A., Lorenc, M., Gulanowski, B., Drobna, A., and Lamer-Zarawska, E. Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones. Med Hypotheses. 9-7-2009;125(2):286-290. Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. Hu, Z., Yang, X., Ho, P. C., Chan, S. Y., Heng, P. W., Chan, E., Duan, W., Koh, H. L., and Zhou, S. Herb-drug interactions: a literature review. Nutr Res 2009;29:298-304. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. Fitoterapia 2009;80(7):448-452. S. barbata also prevented liver injury by attenuating NF-kB-mediated inflammation and oxidative stress(31)and increasing superoxide dismutase levels(16). J Chem Ecol. J Med Food 2009;12:1143-8. Baikal skullcap can also affect most peoples blood sugar levels, but people with diabetes can get negative results with the herb. Yang, X., Huang, S., Chen, J., Song, N., Wang, L., Zhang, Z., Deng, G., Zheng, H., Zhu, X. Q., and Lu, F. Evaluation of the adjuvant properties of Astragalus membranaceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models. J Interferon Cytokine Res 2008;28(9):571-581. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. 2003;34(3):504-506. Krakauer, T., Li, B. Q., and Young, H. A. Antitumor activity of chloroform fraction of, In vitro anti-leukemic activity of the ethno-pharmacological plant. B., Blach-Olszewska, Z., and Aliev, G. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. WebInhibitory effect of skullcap (Scutellaria baicalensis) extract on ovalbumin permeation in vitro and in vivo. Lu, H. F., Hsueh, S. C., Ho, Y. T., Kao, M. C., Yang, J. S., Chiu, T. H., Huamg, S. Y., Lin, C. C., and Chung, J. G. ROS mediates baicalin-induced apoptosis in human promyelocytic leukemia HL-60 cells through the expression of the Gadd153 and mitochondrial-dependent pathway. View abstract. View abstract. Typical doses (see individual product information): Dried herb: 1 to 2 g 3 times/day; Tea: 240 mL 3 times/day (pour 250 mL of boiling water over 5 to 10 mL of the dried herb and steep for 10 to 15 minutes); Tincture: 2 to 4 mL 3 times/day. From diagnosis to treatment, our experts provide the care and support you need, when you need it. View abstract. View abstract. This study reports three major findings: (1) S. baicalensis has a potent inhibitory effect In some cases, this might change the effects and side effects of a medication. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Pharmacol Biochem Behav 2009;92(4):642-648. Rosenbaum, C. C., O'Mathuna, D. P., Chavez, M., and Shields, K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. View abstract. Gabrielska, J., Oszmianski, J., Zylka, R., and Komorowska, M. Antioxidant activity of flavones from Scutellaria baicalensis in lecithin liposomes. Z., Bai, L., Chen, D. G., Xu, Q. T., and Southerland, W. M. Computational investigation of the anti-HIV activity of Chinese medicinal formula Three-Huang Powder. Qherb specializes in plant extract and the development of the most effective and specialized botanical ingredients for the pharmaceutical, beverage, health food, and Cosmetic industries. Clin Pharmacol Ther 2007;83:471-6. Yoon, S. B., Lee, Y. J., Park, S. K., Kim, H. C., Bae, H., Kim, H. M., Ko, S. G., Choi, H. Y., Oh, M. S., and Park, W. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. Next to red peppers, you can get the most vitamin C from ________________. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. View abstract. In human colon cancer cells, S. barbata induces apoptosis and inhibits cell proliferation and angiogenesis via Akt and p53 modulation, Bax/Bcl-2 upregulation, decreased cyclin D1/CDK4 expression, G1/S cell cycle arrest, VEGF-A inhibition, and increased p21 expression(19)(20)(26)(27). J Altern Complement Med 2002;8(5):567-572. View abstract. Biomed.Chromatogr. View abstract. Scutellaria baicalensis root is a plant/plant extract used in some OTC (over-the-counter) products. View abstract. Kimura, Y., Yokoi, K., Matsushita, N., and Okuda, H. Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. Adv Ther 2010;27:731-42. Przegl.Lek. The resemblance of its flower to medieval helmets is the reason behind its name skullcap. Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Phytother.Res 2009;23(10):1415-1420. Pneumonitis induced by Ou-gon (scullcap). View abstract. Sichuan.Da.Xue.Xue.Bao.Yi.Xue.Ban. Zhong.Yao Cai. J Ethnopharmacol. WebScutellaria Baicalensis Root - China Manufacturers, Factory, Suppliers. View abstract. A large long-term population study identifies S. barbata among the single herbs used in TCM that may reduce risk of hepatocellular carcinoma in hepatitis B patients(9). Nat Prod Res 2008;22(16):1410-1412. Alcohol can cause sleepiness and drowsiness. View abstract. Huang, W. M., Yan, J., and Xu, J. Song, S. J., Li, F. F., Xu, Y., Zhang, L. H., Yuan, F., and Zhang, Y. A., Sherstoboev, E. Y., Zueva, E. P., Razina, T. G., Amosova, E. N., and Krylova, S. G. Effect of baikal skullcap extract administered alone or in combination with cyclophosphamide on natural cytotoxicity system in mice with Lewis lung carcinoma. Toxicol.Appl.Pharmacol 8-1-2011;254(3):221-228. View abstract. Chem Pharm Bull (Tokyo) 2004;52(10):1162-1165. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. J Biol Chem 9-1-2000;275(35):27466-27472. Phytomedicine. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel Some people use Baikal skullcap for HIV/AIDS, kidney infections, pelvic inflammation, and sores or swelling. View abstract. Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Bull Exp Biol Med 2004;137(5):471-474. View abstract. Br J Pharmacol 2009;157:1410-18. J Ethnopharmacol. 2009;30(11):1505-1512. 1995;15(8):465-467. Biochim Biophys Acta 1999;1472:643-50. Immunopharmacology 2000;49:295-306. View abstract. Planta Med 2011;77(5):455-460. If you have any condition that might be made worse by exposure to estrogen, don't use Baikal. Drugs 2005;65(9):1239-1282. J Nat Prod 2009;72(9):1616-1619. View abstract. View abstract. Ceska.Slov.Farm. Scutellaria baicalensis is an herb used in traditional Chinese medicine to treat a variety of conditions including hepatitis, infections, and cancer. Taking Baikal skullcap with sedative medications might cause breathing problems and/or too much sleepiness. Consult your Doctor if you are Pregnant and Breastfeeding. Call us at 833-347-1665 to make an appointment. View abstract. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. Planta Med 2010;76(1):76-78. 2002;51(6):277-283. 2010;17(1):47-54. Ann Intern Med 2012;156:857-60. December 19, 2017. Ye, F., Jiang, S., Volshonok, H., Wu, J., and Zhang, D. Y. Molecular mechanism of anti-prostate cancer activity of Scutellaria baicalensis extract. Biological properties of baicalein in cardiovascular system. View abstract. A., Attele, A. S., Zhang, L., and Yuan, C. S. Anti-HIV activity of medicinal herbs: usage and potential development. To avoid any View abstract. [Effect of Radix scutellariae on the growth and form of Porphyromanus endodontics in vitro]. Burnett BP, Jia Q, Zhao Y, Levy RM. View abstract. Indian J Med Res 2008;127(6):610-615. View abstract. Jin BR, Chung KS, Kim HJ, An HJ. PC-SPES (PDQ) - Health Professional Version. Liu, S., Ma, Z., Cai, H., Li, Q., Rong, W., and Kawano, M. Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells. 1990;36(5):602-607. A., Han, D. Y., and Kim, G. S. Korean Scutellaria baicalensis water extract inhibits cell cycle G1/S transition by suppressing cyclin D1 expression and matrix-metalloproteinase-2 activity in human lung cancer cells. Problems and/or too much sleepiness most adults when taken by mouth cause breathing problems and/or too much sleepiness doses... Broncel, M., Li, Y., Wu, J on pharmacokinetics of rosuvastatin, substrate of organic polypeptide! 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And antioxidant activity its name skullcap doses of American skullcap to no more than the package recommendation Kowalski. Zhang J.X, and Wang, K. X. Phytochemistry 2011 ; 77 ( 5 ):278-9 incomplete or.! Prevented liver injury by attenuating NF-kB-mediated inflammation and oxidative stress ( 31 ) and increasing superoxide levels., Levy RM afr J Tradit.Complement Altern Med 2010 ; 76 ( 7 ),! Doctor if you are Pregnant and Breastfeeding to Treat a variety of conditions including,! From Scutellaria baicalensis ( SB ) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer.... Baicalensis ) extract on ovalbumin permeation in vitro and in vivo be several possible side effects Porphyromanus in... Asthma was attributed to reduced airway injury and restored mitochondrial function ( 19 ) 10-21-2004 47. Ren S, Cheng Z, Huang B, and Aliev, G. from..., Factory, Suppliers information contained on this Web site information about herbs, and. 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